MORF4L1

MORF4L1 (Mortality Factor 4 Like 1) is a Protein Coding gene. Diseases associated with MORF4L1 include Paraneoplastic Cerebellar Degeneration. Among its related pathways are Chromatin organization and Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include chromatin binding and protein N-terminus binding. An important paralog of this gene is MORF4L2.

Full Name

MORF4L1

Function

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Biological Process

Cell population proliferation Source: Ensembl
Chromatin organization Source: UniProtKB-KW
Double-strand break repair via homologous recombination Source: UniProtKB
Histone acetylation Source: GO_Central
Histone deacetylation Source: UniProtKB
Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Positive regulation of double-strand break repair via homologous recombination Source: ComplexPortal
Positive regulation of transcription, DNA-templated Source: ComplexPortal
Regulation of apoptotic process Source: ComplexPortal
Regulation of cell cycle Source: ComplexPortal
Regulation of double-strand break repair Source: ComplexPortal
Regulation of growth Source: UniProtKB-KW

Cellular Location

Nucleus