PPBP
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. [provided by RefSeq]
Full Name
PPBP
Function
LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-273, NAP-274, NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to bacteriumIEA:UniProtKB-KW
Glucose transmembrane transportManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Killing of cells of another organismIDA:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell divisionIEA:UniProtKB-KW
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to bacteriumIEA:UniProtKB-KW
Glucose transmembrane transportManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Killing of cells of another organismIDA:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell divisionIEA:UniProtKB-KW
Cellular Location
Secreted
PTM
Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).
Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.
NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils.
NAP-273 and NAP-274 seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.
Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.
NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils.
NAP-273 and NAP-274 seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets.
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Anti-PPBP antibodies
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CompareTarget: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 59418
Application*: WB, N, EC
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3B9
Application*: E, WB
Target: PPBP
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L323
Application*: N, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L322
Application*: N, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: 12
Application*: WB, IC, P, C, E, IP, IF, F
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 186701
Application*: WB, N, EC
Target: PPBP
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 159742
Application*: WB, N
Target: PPBP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 159703
Application*: WB, EC
Target: PPBP
Specificity: Human
Target: PPBP
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0211-23B23
Application*: WB, B/N
Target: PPBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBCNC-689
Application*: E, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-688
Application*: E, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNC-102
Application*: E
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-4299
Application*: WB, IC, P, IH-F, E, IP, IF, F
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2646
Application*: WB, N
Target: PPBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P538
Application*: E
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2374
Application*: F, IH
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2359
Application*: WB, N, E(Cap)
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C2358
Application*: E, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBYY-C0706
Application*: F, IS
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYY-C0692
Application*: F
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H134
Application*: F
Target: PPBP
Host: Rat
Antibody Isotype: IgM
Specificity: Mouse
Clone: 734110
Application*: F
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 358426
Application*: F, IH, MC
Target: PPBP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-3042
Application*: WB, EC
Target: PPBP
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-3041
Application*: N, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3040
Application*: N, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: CBFYC-3039
Application*: WB, IC, P, C, E, IP, IF, F
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NYRhNAP-2
Application*: E, IP, IH, WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0645
Application*: E, I, WB
Target: PPBP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1645
Application*: WB
Target: PPBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0429
Application*: E
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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