PTPN12

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
Full Name
protein tyrosine phosphatase, non-receptor type 12
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503).
Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).
Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).
Biological Process
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ERBB signaling pathwayTAS:Reactome
Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTAS:Reactome
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Tissue regenerationIEA:Ensembl
Cellular Location
Cytoplasm
Cell junction, focal adhesion
Cell projection, podosome
Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.
PTM
Phosphorylated by STK24/MST3 and this results in inhibition of its activity.
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Anti-PTPN12 antibodies

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Rabbit Anti-PTPN12 Recombinant Antibody (D4W7W) (CBMAB-CP2141-LY)

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Target: PTPN12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D4W7W
Application*: WB, IP
Datasheet SDS

Mouse Anti-PTPN12 Recombinant Antibody (AG10) (CBMAB-CP2140-LY)

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Target: PTPN12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: AG10
Application*: WB, IP
Datasheet SDS

Mouse Anti-PTPN12 Recombinant Antibody (F-12) (CBMAB-P3425-YC)

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Target: PTPN12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: F-12
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-PTPN12 Recombinant Antibody (AG25) (CBMAB-P3424-YC)

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Target: PTPN12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Rat
Clone: AG25
Application*: IP, WB
Datasheet SDS

Mouse Anti-PTPN12 Recombinant Antibody (4G6) (CBMAB-P3423-YC)

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Target: PTPN12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4G6
Application*: E, P, WB
Datasheet SDS

Human Recombinant PTPN12, Active protein, GST Tag (V2LY-0526-LY6411)

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Target: PTPN12
Expressed Host: E. coli
Sequence: Amino Acid: 1-355
Tag: GST Tag
Datasheet SDS

Human Recombinant PTPN12 protein, GST Tag (V2LY-0526-LY6410)

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Target: PTPN12
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-355
Tag: GST Tag
Datasheet SDS

Human Recombinant PTPN12 protein (V2LY-0526-LY6409)

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Target: PTPN12
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-355
Datasheet SDS

Rabbit Anti-PTPN12 Recombinant Antibody (CB-5-2F8) (CBMAB-BT072LY)

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Target: PTPN12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CB-5-2F8
Application*: WB, IP, IHC, ICC
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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