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Mouse Anti-PTPN12 Recombinant Antibody (AG10) (CBMAB-CP2140-LY)

The product is antibody recognizes PTPN12. The antibody AG10 immunoassay techniques such as: WB,IP.
See all PTPN12 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
AG10
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with human PTP-PEST recombinant protein. The antibody recognizes an epitope within the amino-terminal 305 residues.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein tyrosine phosphatase, non-receptor type 12
Entrez Gene ID
Human5782
Mouse19248
Rat117255
Monkey721538
UniProt ID
HumanQ05209
MouseP35831
RatG3V7Q4
MonkeyF7EGH9
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503).
Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).
Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).
Biological Process
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ERBB signaling pathwayTAS:Reactome
Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTAS:Reactome
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Tissue regenerationIEA:Ensembl
Cellular Location
Cytoplasm
Cell junction, focal adhesion
Cell projection, podosome
Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.
PTM
Phosphorylated by STK24/MST3 and this results in inhibition of its activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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