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Rabbit Anti-PTPN12 Recombinant Antibody (CB-5-2F8) (CBMAB-BT072LY)

The product is antibody recognizes PTPN12. The antibody CB-5-2F8 immunoassay techniques such as: WB, IP, IHC, ICC.
See all PTPN12 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CB-5-2F8
Antibody Isotype
IgG
Application
WB, IP, IHC, ICC

Basic Information

Immunogen
aa 499-780
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein tyrosine phosphatase, non-receptor type 12
Entrez Gene ID
Human5782
Mouse19248
UniProt ID
HumanQ05209
MouseP35831
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503).
Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).
Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).
Biological Process
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ERBB signaling pathwayTAS:Reactome
Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTAS:Reactome
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Tissue regenerationIEA:Ensembl
Cellular Location
Cytoplasm
Cell junction, focal adhesion
Cell projection, podosome
Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.
PTM
Phosphorylated by STK24/MST3 and this results in inhibition of its activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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