Rabbit Anti-PTPN12 Recombinant Antibody (D4W7W) (CBMAB-CP2141-LY)

Name: Rabbit Anti-PTPN12 Recombinant Antibody (D4W7W)
SKU: CBMAB-CP2141-LY
Rating: 5 (1 reviews)

See all PTPN12 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D4W7W

Application

WB, IP

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg747 of human PTP-PEST protein.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

protein tyrosine phosphatase, non-receptor type 12

Entrez Gene ID

Human	5782
Mouse	19248
Rat	117255

UniProt ID

Human	Q05209
Mouse	P35831
Rat	G3V7Q4

Function

Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503).
Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).
Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172).

Biological Process

Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ERBB signaling pathwayTAS:Reactome
Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTAS:Reactome
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Tissue regenerationIEA:Ensembl

Cellular Location

Cytoplasm
Cell junction, focal adhesion
Cell projection, podosome
Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.

PTM

Phosphorylated by STK24/MST3 and this results in inhibition of its activity.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-PTPN12 Recombinant Antibody (D4W7W)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-PTPN12 Recombinant Antibody (CB-5-2F8) (CAT#: CBMAB-BT072LY)

Human Recombinant PTPN12 protein (CAT#: V2LY-0526-LY6409)

Mouse Anti-PTPN12 Recombinant Antibody (4G6) (CAT#: CBMAB-P3423-YC)

Mouse Anti-PTPN12 Recombinant Antibody (F-12) (CAT#: CBMAB-P3425-YC)

Human Recombinant PTPN12, Active protein, GST Tag (CAT#: V2LY-0526-LY6411)

Mouse Anti-PTPN12 Recombinant Antibody (AG25) (CAT#: CBMAB-P3424-YC)

Mouse Anti-PTPN12 Recombinant Antibody (AG10) (CAT#: CBMAB-CP2140-LY)

Human Recombinant PTPN12 protein, GST Tag (CAT#: V2LY-0526-LY6410)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry