SLIT2

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Slit Guidance Ligand 2

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

Biological Process aortic valve morphogenesisISS:BHF-UCL
Biological Process apoptotic process involved in luteolysisManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process axon extension involved in axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process branching morphogenesis of an epithelial tubeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cellular response to heparinManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process chemorepulsion involved in postnatal olfactory bulb interneuron migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process corticospinal neuron axon guidance through spinal cordManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process induction of negative chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process motor neuron axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of actin filament polymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell growthManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cellular response to growth factor stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of lamellipodium assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of leukocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of monocyte chemotaxisISS:BHF-UCL
Biological Process negative regulation of mononuclear cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of neutrophil chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of retinal ganglion cell axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of small GTPase mediated signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of smooth muscle cell chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of smooth muscle cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of vascular permeabilityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of axonogenesisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process pulmonary valve morphogenesisISS:BHF-UCL
Biological Process response to cortisolManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process retinal ganglion cell axon guidanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Roundabout signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process ureteric bud developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ventricular septum morphogenesisISS:BHF-UCL

Secreted
The C-terminal cleavage protein is more diffusible than the larger N-terminal protein that is more tightly cell associated.