SYNCRIP

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20.

synaptotagmin binding cytoplasmic RNA interacting protein

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

Biological Process cellular response to interferon-gammaIDA:UniProtKB1 Publication
Biological Process CRD-mediated mRNA stabilizationIDA:ComplexPortal2 Publications
Biological Process mRNA modificationIDA:ComplexPortal
Biological Process mRNA splicing, via spliceosomeIC:UniProtKB1 Publication
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayIDA:ComplexPortal2 Publications
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIDA:ComplexPortal
Biological Process negative regulation of translationIDA:UniProtKB1 Publication
Biological Process osteoblast differentiationHDA:UniProtKB1 Publication
Biological Process positive regulation of cytoplasmic translationIDA:ComplexPortal2 Publications
Biological Process positive regulation of DNA demethylationIC:ComplexPortal
Biological Process RNA processingTAS:ProtInc1 Publication
Biological Process RNA splicingTAS:ProtInc1 Publication

Cytoplasm
Microsome
Endoplasmic reticulum
Nucleus
The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity).
Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity).
Isoform 1
Nucleus, nucleoplasm
Expressed predominantly in the nucleoplasm.
Isoform 2
Nucleus, nucleoplasm
Expressed predominantly in the nucleoplasm.
Isoform 3
Nucleus, nucleoplasm
Expressed predominantly in the nucleoplasm.

Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity).