WNT10B

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Wnt Family Member 10B

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

Biological Process bone trabecula formation Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:BHF-UCL1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to cAMP Source:Ensembl
Biological Process cellular response to parathyroid hormone stimulus Source:Ensembl
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process chondrocyte differentiation Source:UniProtKB1 Publication
Biological Process epithelial cell differentiation Source:Ensembl
Biological Process fat cell differentiation Source:Ensembl
Biological Process fungiform papilla development Source:Ensembl
Biological Process G2/M transition of mitotic cell cycle Source:Ensembl
Biological Process hematopoietic stem cell proliferation Source:BHF-UCL1 Publication
Biological Process lipid metabolic process Source:Ensembl
Biological Process myoblast development Source:Ensembl
Biological Process myoblast differentiation involved in skeletal muscle regeneration Source:Ensembl
Biological Process negative regulation of cold-induced thermogenesis Source:YuBioLabBy Similarity
Biological Process negative regulation of epithelial cell proliferation Source:Ensembl
Biological Process negative regulation of fat cell differentiation Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process neuron differentiation Source:UniProtKB
Biological Process osteoblast differentiation Source:Ensembl
Biological Process positive regulation of apoptotic process Source:BHF-UCL1 Publication
Biological Process positive regulation of bone mineralization Source:Ensembl
Biological Process positive regulation of canonical Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of DNA-binding transcription factor activity Source:Ensembl
Biological Process positive regulation of epithelial cell differentiation Source:Ensembl
Biological Process positive regulation of G2/M transition of mitotic cell cycle Source:Ensembl
Biological Process positive regulation of hematopoietic stem cell proliferation Source:Ensembl
Biological Process positive regulation of osteoblast differentiation Source:Ensembl
Biological Process positive regulation of RNA polymerase II transcription preinitiation complex assembly Source:Ensembl
Biological Process positive regulation of T cell differentiation Source:Ensembl
Biological Process positive regulation of timing of anagen Source:Ensembl
Biological Process protein stabilization Source:BHF-UCL1 Publication
Biological Process regulation of proteasomal ubiquitin-dependent protein catabolic process Source:Ensembl
Biological Process regulation of skeletal muscle tissue development Source:Ensembl
Biological Process sensory perception of taste Source:Ensembl
Biological Process skeletal muscle fiber development Source:Ensembl
Biological Process smoothened signaling pathway Source:Ensembl
Biological Process T cell differentiation Source:Ensembl
Biological Process transcription by RNA polymerase II Source:Ensembl

Secreted, extracellular space, extracellular matrix
Secreted

Split-hand/foot malformation 6 (SHFM6):
A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have intellectual disability, ectodermal and craniofacial findings, and orofacial clefting.
Tooth agenesis, selective, 8 (STHAG8):
A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG8 inheritance is autosomal dominant.

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.