BTC

This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]

Full Name

Betacellulin

Function

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Biological Process

Epidermal growth factor receptor signaling pathway Source: GO_Central
ERBB2 signaling pathway Source: Reactome
MAPK cascade Source: Reactome
Membrane organization Source: Reactome
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
Positive regulation of cell differentiation Source: Ensembl
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of epidermal growth factor-activated receptor activity Source: GO_Central
Positive regulation of fibroblast proliferation Source: Ensembl
Positive regulation of mitotic nuclear division Source: GO_Central
Positive regulation of protein kinase B signaling Source: Reactome
Positive regulation of urine volume Source: Ensembl
Regulation of cell motility Source: Reactome
Signal transduction Source: Reactome

Cellular Location

Betacellulin: Extracellular space
Probetacellulin: Cell membrane

Topology

Extracellular: 32-118 aa
Helical: 119-139 aa
Cytoplasmic: 140-178 aa