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CA12

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]CA12 (Carbonic Anhydrase 12) is a Protein Coding gene. Diseases associated with CA12 include Hyperchlorhidrosis, Isolated and Degenerative Disc Disease. Among its related pathways are Nitrogen metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.Reversible hydration of carbon dioxide.
Full Name
Carbonic Anhydrase 12
Function
Reversible hydration of carbon dioxide.
Biological Process
Bicarbonate transport Source: Reactome
Chloride ion homeostasis Source: UniProtKB
One-carbon metabolic process Source: GO_Central
Cellular Location
Cell membrane; Membrane
Involvement in disease
Hyperchlorhidrosis, isolated (HYCHL): An autosomal recessive disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.
Topology
Extracellular: 25-301 aa
Helical: 302-322 aa
Cytoplasmic: 323-354 aa

Anti-CA12 antibodies

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Mouse Anti-CA12 Recombinant Antibody (CBXC-1869) (CBMAB-C3717-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1869
Application*: WB, IH, P

Mouse Anti-CA12 Recombinant Antibody (CBXC-1094) (CBMAB-C3716-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1094
Application*: WB

Mouse Anti-CA12 Recombinant Antibody (CBXC-2187) (CBMAB-C3714-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2187
Application*: E

Mouse Anti-CA12 Recombinant Antibody (CBXC-2331) (CBMAB-C3713-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2331
Application*: IH

Mouse Anti-CA12 Recombinant Antibody (CBXC-2067) (CBMAB-C3712-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2067
Application*: WB, IH

Mouse Anti-CA12 Recombinant Antibody (CBXC-1904) (CBMAB-C3711-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1904
Application*: WB, IH

Mouse Anti-CA12 Recombinant Antibody (CBFYC-0686) (CBMAB-C0740-FY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0686
Application*: IC, IF

Mouse Anti-CA12 Recombinant Antibody (CBFYC-0685) (CBMAB-C0739-FY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0685
Application*: WB

Mouse Anti-CA12 Recombinant Antibody (CBFYC-0684) (CBMAB-C0738-FY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-0684
Application*: P, WB

Mouse Anti-CA12 Recombinant Antibody (CBFYC-0029) (CBMAB-C0036-FY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0029
Application*: F, IC, IF

Mouse Anti-CA12 Recombinant Antibody (7H81) (CBMAB-C8865-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H81
Application*: E, WB

Mouse Anti-CA12 Recombinant Antibody (4G3) (CBMAB-C6985-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4G3
Application*: P, WB

Mouse Anti-CA12 Recombinant Antibody (4D1) (CBMAB-C6758-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4D1
Application*: IF, WB

Mouse Anti-CA12 Recombinant Antibody (07) (CBMAB-C0093-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 07
Application*: F, IC/IF, IF

Mouse Anti-CA12 Recombinant Antibody (11) (CBMAB-C0193-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11
Application*: F

Mouse Anti-CA12 Recombinant Antibody (01) (CBMAB-C1560-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 01
Application*: EC

Rabbit Anti-CA12 Recombinant Antibody (012) (CBMAB-C1608-LY)

Datasheet SDS
Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 012
Application*: E, P

Mouse Anti-CA12 Recombinant Antibody (04) (CBMAB-C1738-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 04
Application*: IC/IF, IF

Rabbit Anti-CA12 Recombinant Antibody (12) (CBMAB-C2554-LY)

Datasheet SDS
Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 12
Application*: E, WB

Mouse Anti-CA12 Recombinant Antibody (1A6) (CBMAB-C3559-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A6
Application*: P, WB

Mouse Anti-CA12 Recombinant Antibody (1D4) (CBMAB-C3824-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D4
Application*: E, WB

Mouse Anti-CA12 Recombinant Antibody (2C6) (CBMAB-C4805-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C6
Application*: WB, P, IC/IF

Mouse Anti-CA12 Recombinant Antibody (2D6E1) (CBMAB-C4919-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D6E1
Application*: E, WB

Mouse Anti-CA12 Recombinant Antibody (2E9) (CBMAB-C5036-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E9
Application*: IF, WB

Rabbit Anti-CA12 Recombinant Antibody (3) (CBMAB-C5422-LY)

Datasheet SDS
Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 3
Application*: E

Rat Anti-CA12 Recombinant Antibody (336103) (CBMAB-C5532-LY)

Datasheet SDS
Target: CA12
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 336103
Application*: WB

Mouse Anti-CA12 Recombinant Antibody (3F1) (CBMAB-C5987-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F1
Application*: WB

Mouse Anti-CA12 Recombinant Antibody (4) (CBMAB-C6407-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4
Application*: IF/IC

Rat Anti-CA12 Recombinant Antibody (CBYY-C0828) (CBMAB-C2264-YY)

Datasheet SDS
Target: CA12
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C0828
Application*: WB

Mouse Anti-CA12 Recombinant Antibody (CBYY-C0829) (CBMAB-C2265-YY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0829
Application*: WB

Mouse Anti-CA12 Recombinant Antibody (CBYY-C0830) (CBMAB-C2266-YY)

Datasheet SDS
Target: CA12
Host: Mouse
Specificity: Human
Clone: CBYY-C0830
Application*: IF

Mouse Anti-CA12 Recombinant Antibody (CBYY-C0831) (CBMAB-C2267-YY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0831
Application*: IF, WB

Mouse Anti-CA12 Recombinant Antibody (CBYY-C0832) (CBMAB-C2268-YY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0832
Application*: P, WB

Mouse Anti-CA12 Recombinant Antibody (CBYY-C0833) (CBMAB-C2269-YY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0833
Application*: E, WB

Mouse Anti-CA12 Recombinant Antibody (UMAB121) (CBMAB-C9578-LY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: UMAB121
Application*: P

Rabbit Anti-CA12 Recombinant Antibody (D75C6) (CBMAB-CP0056-LY)

Datasheet SDS
Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D75C6
Application*: WB, IP, F

Rabbit Anti-CA12 Recombinant Antibody (D78E4) (CBMAB-CP0057-LY)

Datasheet SDS
Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D78E4
Application*: WB, IP

Rabbit Anti-CA12 Recombinant Antibody (EG442) (CBMAB-EN502-LY)

Datasheet SDS
Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG442
Application*: WB: 1:500~1:1000 ELISA: 1:40000

Mouse Anti-CA12 Recombinant Antibody (CBXC-2909) (CBMAB-C3710-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2909
Application*: WB, IF

Mouse Anti-CA12 Recombinant Antibody (CBXC-2104) (CBMAB-C3709-CQ)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2104
Application*: WB, IF

Mouse Anti-CA12 Recombinant Antibody (CBFYC-0687) (CBMAB-C0741-FY)

Datasheet SDS
Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0687
Application*: F

CA12 Matched Antibody Pair (163) (APMAB-163LY)

Datasheet SDS
Target: CA12
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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