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CA12

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]CA12 (Carbonic Anhydrase 12) is a Protein Coding gene. Diseases associated with CA12 include Hyperchlorhidrosis, Isolated and Degenerative Disc Disease. Among its related pathways are Nitrogen metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.Reversible hydration of carbon dioxide.
Full Name
Carbonic Anhydrase 12
Function
Reversible hydration of carbon dioxide.
Biological Process
Bicarbonate transport Source: Reactome
Chloride ion homeostasis Source: UniProtKB
One-carbon metabolic process Source: GO_Central
Cellular Location
Cell membrane; Membrane
Involvement in disease
Hyperchlorhidrosis, isolated (HYCHL): An autosomal recessive disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.
Topology
Extracellular: 25-301 aa
Helical: 302-322 aa
Cytoplasmic: 323-354 aa
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Anti-CA12 antibodies

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Rat Anti-CA12 Recombinant Antibody (336103) (CBMAB-C5532-LY)

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Target: CA12
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 336103
Application*: WB
Datasheet SDS

Rabbit Anti-CA12 Recombinant Antibody (D78E4) (CBMAB-C5036-LY)

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Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D78E4
Application*: IP, WB
Datasheet SDS

Mouse Anti-CA12 Recombinant Antibody (2D6E1) (CBMAB-C4919-LY)

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Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D6E1
Application*: E
Datasheet SDS

Mouse Anti-CA12 Recombinant Antibody (1D4) (CBMAB-C3824-LY)

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Target: CA12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D4
Application*: E, WB
Datasheet SDS

Mouse Anti-CA12 Recombinant Antibody (04) (CBMAB-C1738-LY)

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Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 04
Application*: IF
Datasheet SDS

Rabbit Anti-CA12 Recombinant Antibody (01) (CBMAB-C1560-LY)

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Target: CA12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 01
Application*: E
Datasheet SDS

Mouse Anti-CA12 Recombinant Antibody (11) (CBMAB-C0193-LY)

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Target: CA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11
Application*: FC
Datasheet SDS

CA12 Matched Antibody Pair (163) (APMAB-163LY)

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Target: CA12
Specificity: Human
Datasheet SDS

Mouse Anti-CA12 Recombinant Antibody (CBFYC-0687) (CBMAB-C0741-FY)

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Target: CA12
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0687
Application*: E, WB, P, IF, IP
Datasheet SDS

Mouse Anti-CA12 Recombinant Antibody (CBFYC-0029) (CBMAB-C0036-FY)

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Target: CA12
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-0029
Application*: E, WB, P, IF, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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