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CAPN1

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Full Name
Calpain 1
Function
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:21531719, PubMed:2400579).
Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407).
Biological Process
Cornification Source: Reactome
Extracellular matrix disassembly Source: Reactome
Mammary gland involution Source: Ensembl
Neutrophil degranulation Source: Reactome
Positive regulation of cell population proliferation Source: ProtInc
Proteolysis Source: UniProtKB
Receptor catabolic process Source: Ensembl
Regulation of catalytic activity Source: UniProtKB
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Regulation of NMDA receptor activity Source: ARUK-UCL
Self proteolysis Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm. Translocates to the plasma membrane upon Ca2+ binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719).
Involvement in disease
Spastic paraplegia 76, autosomal recessive (SPG76): A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
PTM
Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.

Anti-CAPN1 antibodies

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Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: 15C10
Application*: E, IP, WB
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: 156
Application*: WB, IF
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Rabbit
Clone: CBXC-2341
Application*: WB, F, E, IH, IF, C
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: CBXC-2432
Application*: WB, E, IP, P
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: CBXC-2428
Application*: WB, IF
Target: CAPN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: SP81
Application*: WB, IH, P
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: CBFYC-0791
Application*: E, IP, WB
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0790
Application*: WB, P
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: CBFYM-0894
Application*: E, IP, WB
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Hamster, Human, Mouse, Pig, Rabbit, Rat
Clone: CBFYM-0893
Application*: F, IC, IF, C, IH, WB
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9A10-9A9-3H2
Application*: WB, F, P
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: CBLC085-LY
Application*: E, WB, P, IP
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 28F3
Application*: IP
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P035
Application*: WB, IC, P, C, E
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P034
Application*: WB, IC, P, C, E
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Pig, Rat
Clone: CBYY-C0897
Application*: IC, WB
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Pig, Rat
Clone: 6D196
Application*: C, WB
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Mouse, Rat
Clone: 2Q42
Application*: E, IC, IP, WB
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Human, Pig
Clone: 2H2A7C2
Application*: WB, IC, IC/IF
Target: CAPN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1376CT809.24.85
Application*: WB, P
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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