CBX5

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Full Name
Chromobox 5
Alternative Names
Chromobox 5; Chromobox Homolog 5 (HP1 Alpha Homolog, Drosophila); Heterochromatin Protein 1 Homolog Alpha; Antigen P25; HP1A; Chromobox Homolog 5 (Drosophila HP1 Alpha); Heterochromatin Protein 1-Alpha; HP1 Alpha Homolog (Drosophila); Epididymis Luminal Protein 25;
Function
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Biological Process
Blood coagulation Source: Reactome
Cellular response to DNA damage stimulus Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Nucleus; Chromosome; Centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity).
PTM
Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Ubiquitinated.
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Anti-CBX5 antibodies

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Mouse Anti-CBX5 Recombinant Antibody (CBT50) (V2LY-0625-LY3839)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT50
Application*: IF, IC, WB, P
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (CBT3669) (V2LY-0625-LY383)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT3669
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (CBT4197) (V2LY-0625-LY382)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT4197
Application*: WB, IC, F
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (CBT2383) (V2LY-0625-LY370)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBT2383
Application*: WB, IH, IC
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (CBT732) (V2LY-0625-LY3321)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBT732
Application*: WB, IF, IC
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (EC100) (V2LY-0624-LY100)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC100
Application*: WB, P
Datasheet SDS

CBX5 Matched Antibody Pair (193) (APMAB-193LY)

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Target: CBX5
Specificity: Human
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (3G2-H10-A6) (CBMAB-C6132-LY)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 3G2-H10-A6
Application*: WB, IF
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (3A11F8) (CBMAB-C5633-LY)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 3A11F8
Application*: E, WB, IF/C, F
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (1E11-3A10) (CBMAB-C3912-LY)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1E11-3A10
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-CBX5 Recombinant Antibody (1B10B2) (CBMAB-C3613-LY)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 1B10B2
Application*: E, IF, P, WB
Datasheet SDS

Rabbit Anti-CBX5 Recombinant Antibody (CBFYH-0060) (CBMAB-H0879-FY)

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Target: CBX5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYH-0060
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-CBX5 Monoclonal Antibody (CBFYH-2924) (CBMAB-H0872-FY)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2924
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-CBX5 Monoclonal Antibody (CBFYH-2923) (CBMAB-H0380-FY)

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Target: CBX5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-2923
Application*: E, IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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