CCL11

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq]

Full Name

chemokine (C-C motif) ligand 11

Function

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956).
Binds to CCR3 (PubMed:8631813).

Biological Process

Actin filament organization Source: Ensembl
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cell adhesion Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Chronic inflammatory response Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
ERK1 and ERK2 cascade Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Learning or memory Source: ARUK-UCL
Lymphocyte chemotaxis Source: GO_Central
Mammary duct terminal end bud growth Source: Ensembl
Mast cell chemotaxis Source: Ensembl
Modulation of age-related behavioral decline Source: ARUK-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of neurogenesis Source: ARUK-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell shape Source: UniProtKB
Response to interleukin-13 Source: Ensembl
Response to interleukin-4 Source: Ensembl
Response to radiation Source: ProtInc
Response to virus Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.