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Mouse Anti-CCL11 Recombinant Antibody (43911) (CBMAB-C1291-LY)

This product is antibody recognizes CCL11. The antibody 43911 immunoassay techniques such as: WB, IHC, Neutralization, ELISA (Cap).
See all CCL11 antibodies
Published Data
Fig 1 Representative field of Dcxpositive cells for each treatment group (n 5 6–10 mice) treated four times over 10 days. i.p., intraperitoneal. Scale bar, 100 mm.
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Fig.2 Eotaxin-1 expression in COPD lung tissue. Lung sections from a control subject without lung disease or COPD.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
43911
Antibody Isotype
IgG1
Application
WB, IHC, Neutralization, ELISA (Cap)

Basic Information

Immunogen
E. coli-derived recombinant human CCL11/Eotaxin, Gly24-Pro97, Accession # P51671
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
chemokine (C-C motif) ligand 11
Introduction
CCL11 (C-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include Asthma and Human Immunodeficiency Virus Type 1. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CCL2.
Entrez Gene ID
6356
UniProt ID
P51671
Alternative Names
C-C Motif Chemokine Ligand 11; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin); Chemokine (C-C Motif) Ligand 11; Eosinophil Chemotactic Protein; Eotaxin-1; SCYA11; Small-Inducible Cytokine A11; C-C Motif Chemokine 11; Eotaxin;
Function
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956).
Binds to CCR3 (PubMed:8631813).
Biological Process
Actin filament organization Source: Ensembl
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cell adhesion Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Chronic inflammatory response Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
ERK1 and ERK2 cascade Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Learning or memory Source: ARUK-UCL
Lymphocyte chemotaxis Source: GO_Central
Mammary duct terminal end bud growth Source: Ensembl
Mast cell chemotaxis Source: Ensembl
Modulation of age-related behavioral decline Source: ARUK-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of neurogenesis Source: ARUK-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell shape Source: UniProtKB
Response to interleukin-13 Source: Ensembl
Response to interleukin-4 Source: Ensembl
Response to radiation Source: ProtInc
Response to virus Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.

Da Ae Kim, S. J. P., Lee, J. Y., Kim, J. H., Lee, S., Lee, E., Jang, I. Y., ... & Kim, B. J. (2021). Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults. Endocrinology and Metabolism, 36(2), 455.

Kurogoushi, R., Hasegawa, T., Akazawa, Y., Iwata, K., Sugimoto, A., Yamaguchi-Ueda, K., ... & Iwamoto, T. (2021). Fibroblast growth factor 2 suppresses the expression of CC motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells. Experimental and Therapeutic Medicine, 22(6), 1-8.

Jung, H. W., Park, J. H., & Kim, B. J. (2021). Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults.

Park, S. J., Da Ae Kim, J. Y. L., & Kim, B. J. (2021). In Vitro Effect of CCL11 on Myogenic Differentiation and Its Relevance With Sarcopenia Parameters in Older Adults. Journal of the Endocrine Society, 5(Suppl 1), A234.

Wang, R., & Huang, K. (2020). CCL11 increases the proportion of CD4+ CD25+ Foxp3+ Treg cells and the production of IL‑2 and TGF‑β by CD4+ T cells via the STAT5 signaling pathway. Molecular medicine reports, 21(6), 2522-2532.

Wang, W., Huang, C. Y., Wang, Z. P., Xu, S. S., Qian, T. Y., Chen, Y. D., & Wu, W. G. (2019). Serum CC motif ligand 11/eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Journal of medical biochemistry, 38(3), 353.

Kuznik, B. I., Davydov, S. O., Stepanov, A. V., Guseva, E. S., Smolyakov, Y. N., Tsybikov, N. N., & Magen, E. (2018). The role of growth differentiation factors 11 and 15 (GDF11, GDF15), eotaxin 1 (CCL11) and junctional adhesion molecule a (JAMA) in the regulation of blood pressure in women with essential hypertension. MOJ Gerontology & Geriatrics, 3(1), 71-75.

Polacchini, A., Girardi, D., Falco, A., Zanotta, N., Comar, M., De Carlo, N. A., & Tongiorgi, E. (2018). Distinct CCL2, CCL5, CCL11, CCL27, IL-17, IL-6, BDNF serum profiles correlate to different job-stress outcomes. Neurobiology of stress, 8, 82-91.

Kang, W. S., Kim, Y. J., Park, H. J., Kim, S. K., Paik, J. W., & Kim, J. W. (2018). Association of CCL11 promoter polymorphisms with schizophrenia in a Korean population. Gene, 656, 80-85.

Nieh, S. (2017). The role of cancer-associated fibroblast-induced chemokine ligand 11 in tumor microenvironment contributes to the progression of oral cancer.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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