CD200
CD200 (CD200 Molecule) is a Protein Coding gene. Diseases associated with CD200 include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Full Name
CD200 Molecule
Alternative Names
CD200 Molecule; CD200 Antigen; Antigen Identified By Monoclonal Antibody MRC OX-2; MOX1; MOX2; OX-2 Membrane Glycoprotein; OX-2; MRC;
Function
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Biological Process
Cell-cell adhesion Source: ARUK-UCL
Heterotypic cell-cell adhesion Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of leukocyte activation Source: ARUK-UCL
Negative regulation of macrophage activation Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of matrix metallopeptidase secretion Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Positive regulation of arginase activity Source: ARUK-UCL
Positive regulation of CREB transcription factor activity Source: ARUK-UCL
Positive regulation of protein-glutamine gamma-glutamyltransferase activity Source: ARUK-UCL
Positive regulation of transforming growth factor beta production Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Heterotypic cell-cell adhesion Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of leukocyte activation Source: ARUK-UCL
Negative regulation of macrophage activation Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of matrix metallopeptidase secretion Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Positive regulation of arginase activity Source: ARUK-UCL
Positive regulation of CREB transcription factor activity Source: ARUK-UCL
Positive regulation of protein-glutamine gamma-glutamyltransferase activity Source: ARUK-UCL
Positive regulation of transforming growth factor beta production Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 31-232
Helical: 233-259
Cytoplasmic: 260-278
Helical: 233-259
Cytoplasmic: 260-278
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Anti-CD200 antibodies
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CompareTarget: CD200
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 2
Application*: F
Target: CD200
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG11
Application*: F, IH, In Vivo
Target: Cd200
Sensitivity: 0.053 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Cd200
Sensitivity: 0.0091 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: His Tag
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: hFc Tag
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: Fc Tag
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: His Tag
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: His Tag
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: His & AVI Tag
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: hFc Tag
Target: CD200
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-232
Tag: hFc & AVI Tag
Target: CD200
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3316
Application*: WB
Target: CD200
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2730
Application*: IC, F
Target: CD200
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1107
Application*: N
Target: CD200
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: OX-104
Application*: F
Target: CD200
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C0020
Application*: IF, IP, WB, F
Target: CD200
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-0972
Application*: IF, IP, WB, F
Target: CD200
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 333
Application*: P
Target: CD200
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 005
Application*: E
Target: CD200
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: OX2
Application*: IF, F, E
Target: CD200
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0301
Application*: E, F
Target: CD200
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: OX90
Application*: IF, F, IH, B
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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