CDC14A

CDC14A (Cell Division Cycle 14A) is a Protein Coding gene. Diseases associated with CDC14A include Deafness, Autosomal Recessive 105 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CDC14B.

Cell Division Cycle 14A

Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958).

Cell division Source: UniProtKB-KW
Cilium assembly Source: GO_Central
Microtubule cytoskeleton organization Source: GO_Central
Mitotic cell cycle Source: GO_Central
Mitotic cell cycle arrest Source: GO_Central
Positive regulation of cytokinesis Source: GO_Central
Regulation of exit from mitosis Source: GO_Central
Sensory perception of sound Source: UniProtKB

Centrosome; Spindle pole; Spindle; Nucleus; Kinocilium; Stereocilium. Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity).

Deafness, autosomal recessive, 32, with or without immotile sperm (DFNB32): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB32 is characterized by prelingual, progressive, moderate to profound sensorineural deafness. Some affected men are infertile.