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Mouse Anti-CDC14A (AA 431-531) Recombinant Antibody (CBFYC-1509) (CBMAB-C1568-FY)

This product is mouse antibody that recognizes CDC14A. The antibody CBFYC-1509 can be used for immunoassay techniques such as: ELISA, ICC, WB.
See all CDC14A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1509
Antibody Isotype
IgG2a
Application
ELISA, ICC, WB

Basic Information

Immunogen
CDC14A (NP_003663, 431 a.a.-531 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 431-531

Target

Full Name
Cell Division Cycle 14A
Introduction
CDC14A (Cell Division Cycle 14A) is a Protein Coding gene. Diseases associated with CDC14A include Deafness, Autosomal Recessive 105 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and RET signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CDC14B.
Entrez Gene ID
8556
UniProt ID
Q9UNH5
Alternative Names
Cell Division Cycle 14A; CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog); CDC14 Cell Division Cycle 14 Homolog A; CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae); Dual Specificity Protein Phosphatase CDC14A; EC 3.1.3.16
Function
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958).
Biological Process
Cell division Source: UniProtKB-KW
Cilium assembly Source: GO_Central
Microtubule cytoskeleton organization Source: GO_Central
Mitotic cell cycle Source: GO_Central
Mitotic cell cycle arrest Source: GO_Central
Positive regulation of cytokinesis Source: GO_Central
Regulation of exit from mitosis Source: GO_Central
Sensory perception of sound Source: UniProtKB
Cellular Location
Centrosome; Spindle pole; Spindle; Nucleus; Kinocilium; Stereocilium. Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity).
Involvement in disease
Deafness, autosomal recessive, 32, with or without immotile sperm (DFNB32): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB32 is characterized by prelingual, progressive, moderate to profound sensorineural deafness. Some affected men are infertile.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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