CDC25B

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq]

Full Name

cell division cycle 25 homolog B (S. pombe)

Function

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

Biological Process

Cell division Source: UniProtKB-KW
Female meiosis I Source: Ensembl
G2/M transition of mitotic cell cycle Source: GO_Central
Mitotic cell cycle Source: UniProtKB
Oocyte maturation Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of cytokinesis Source: UniProtKB
Positive regulation of G2/MI transition of meiotic cell cycle Source: GO_Central
Positive regulation of G2/M transition of mitotic cell cycle Source: GO_Central
Positive regulation of mitotic cell cycle Source: UniProtKB
Positive regulation of protein kinase activity Source: Ensembl
Protein phosphorylation Source: UniProtKB

Cellular Location

Centrosome; Spindle pole

PTM

Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.