CDH15

CDH15 (Cadherin 15) is a Protein Coding gene. Diseases associated with CDH15 include Autosomal Dominant Non-Syndromic Intellectual Disability and Hypotrichosis, Congenital, With Juvenile Macular Dystrophy. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH4.

Full Name

Cadherin 15

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.

Biological Process

Adherens junction organization Source: Reactome
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Positive regulation of muscle cell differentiation Source: Reactome

Cellular Location

Cell membrane

Involvement in disease

A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).
Mental retardation, autosomal dominant 3 (MRD3): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Topology

Extracellular: 61-606
Helical: 607-626
Cytoplasmic: 627-814

Anti-CDH15 antibodies

Rat Anti-CDH15 Recombinant Antibody (CBXC-1684) (CBMAB-C3567-CQ)

Datasheet

SDS

Target: CDH15

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse, Rat

Clone: CBXC-1684

Application*: E, WB

Rat Anti-CDH15 Recombinant Antibody (CBXC-1685) (CBMAB-C3566-CQ)

Datasheet

SDS

Target: CDH15

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXC-1685

Application*: E, IC

Mouse Anti-CDH15 Recombinant Antibody (CBFYC-1549) (CBMAB-C1608-FY)

Datasheet

SDS

Target: CDH15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1549

Application*: E, IF, WB

Mouse Anti-CDH15 Recombinant Antibody (CBFYC-1548) (CBMAB-C1607-FY)

Datasheet

SDS

Target: CDH15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBFYC-1548

Application*: E, IF, WB

Rat Anti-CDH15 (AA 22-605) Recombinant Antibody (CBFYM-0990) (CBMAB-M1140-FY)

Datasheet

SDS

Target: CDH15

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse, Rat

Clone: CBFYM-0990

Application*: WB

Rat Anti-CDH15 (AA 22-605) Recombinant Antibody (CBFYM-0989) (CBMAB-M1139-FY)

Datasheet

SDS

Target: CDH15

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYM-0989

Application*: IC

Mouse Anti-CDH15 Recombinant Antibody (CBFYM-0988) (CBMAB-M1138-FY)

Datasheet

SDS

Target: CDH15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0988

Application*: E, IF, WB

Mouse Anti-CDH15 (AA 253-366) Recombinant Antibody (5/M-Cadherin) (CBMAB-M1141-FY)

Datasheet

SDS

Target: CDH15

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Mouse, Rat

Clone: 5/M-Cadherin

Application*: WB, IF

Rat Anti-CDH15 Recombinant Antibody (800512) (CBMAB-C8921-LY)

Datasheet

SDS

Target: CDH15

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 800512

Application*: E, WB

Mouse Anti-CDH15 Recombinant Antibody (12G4) (CBMAB-C2654-LY)

Datasheet

SDS

Target: CDH15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 12G4

Application*: E, IC/IF, WB

Rabbit Anti-CDH15 Recombinant Antibody (EG583) (CBMAB-EN704-LY)

Datasheet

SDS

Target: CDH15

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG583

Application*: WB: 1:500~1:1000 ELISA: 1:10000

Rat Anti-CDH15 Recombinant Antibody (800516) (CBMAB-C10798-LY)

Datasheet

SDS

Target: CDH15

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 800516

Application*: E, IC

Mouse Anti-CDH15 Recombinant Antibody (6D190) (CBMAB-C2072-CN)

Datasheet

SDS

Target: CDH15

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6D190

Application*: E, IF, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)