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Mouse Anti-CDH15 Recombinant Antibody (CBFYC-1548) (CBMAB-C1607-FY)

This product is mouse antibody that recognizes CDH15. The antibody CBFYC-1548 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all CDH15 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBFYC-1548
Antibody Isotype
IgG1
Application
ELISA, IF, WB

Basic Information

Immunogen
Recombinant extracellualr domain of murine M-cadherin
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cadherin 15
Introduction
CDH15 (Cadherin 15) is a Protein Coding gene. Diseases associated with CDH15 include Autosomal Dominant Non-Syndromic Intellectual Disability and Hypotrichosis, Congenital, With Juvenile Macular Dystrophy. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH4.
Entrez Gene ID
12555
UniProt ID
P33146
Alternative Names
Mcad; Cdh14; AI323380
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
Biological Process
Adherens junction organization Source: Reactome
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Positive regulation of muscle cell differentiation Source: Reactome
Cellular Location
Cell membrane
Involvement in disease
A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).
Mental retardation, autosomal dominant 3 (MRD3): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Topology
Extracellular: 61-606
Helical: 607-626
Cytoplasmic: 627-814
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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