CGA

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Full Name
Glycoprotein Hormones, Alpha Polypeptide
Function
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Biological Process
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Peptide hormone processing Source: Reactome
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of steroid biosynthetic process Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of signaling receptor activity Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: Reactome
Thyroid hormone generation Source: GO_Central
Cellular Location
Secreted
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Anti-CGA antibodies

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Mouse Anti-CGA Monoclonal Antibody (CBFYH-2937) (CBMAB-H0904-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2937
Application*: E, P
Datasheet SDS

Mouse Anti-CGA Recombinant Antibody (CBFYH-2910) (CBMAB-H0903-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human, Rat
Clone: CBFYH-2910
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-CGA Monoclonal Antibody (CBFYH-2936) (CBMAB-H0902-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2936
Application*: WB, IH, IF, E, IP
Datasheet SDS

Mouse Anti-CGA Monoclonal Antibody (CBFYH-2934) (CBMAB-H0900-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2934
Application*: IH
Datasheet SDS

Mouse Anti-CGA Monoclonal Antibody (CBFYH-2932) (CBMAB-H0897-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2932
Application*: E, P
Datasheet SDS

Mouse Anti-CGA Monoclonal Antibody (CBFYH-2931) (CBMAB-H0896-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2931
Application*: E, WB
Datasheet SDS

Rabbit Anti-CGA Monoclonal Antibody (CBFYH-2930) (CBMAB-H0894-FY)

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Target: CGA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2930
Application*: P
Datasheet SDS

Rabbit Anti-CGA Monoclonal Antibody (CBFYH-2929) (CBMAB-H0893-FY)

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Target: CGA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2929
Application*: WB, E, IH
Datasheet SDS

Mouse Anti-CGA Monoclonal Antibody (CBFYH-2928) (CBMAB-H0891-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYH-2928
Application*: P
Datasheet SDS

Mouse Anti-CGA Recombinant Antibody (CBFYH-0071) (CBMAB-H0637-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0071
Application*: WB, IH
Datasheet SDS

Mouse Anti-CGA Recombinant Antibody (CBFYH-0080) (CBMAB-H0501-FY)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0080
Application*: E
Datasheet SDS

Human Recombinant CGA protein, Fc Tag (V2LY-0526-LY3128)

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Target: CGA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-116
Tag: Fc Tag
Datasheet SDS

Human Recombinant CGA protein, His Tag (V2LY-0526-LY3127)

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Target: CGA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-116
Tag: His Tag
Datasheet SDS

Human Recombinant CGA protein (V2LY-0526-LY3126)

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Target: CGA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-116
Datasheet SDS

Human Recombinant FSHA & FSHB protein, hFc Tag (V2LY-0526-LY4214)

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Target: CGA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-116, 1-129
Tag: hFc Tag
Datasheet SDS

Mouse Anti-CGA Recombinant Antibody (CBT2981) (V2LY-0625-LY199)

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Target: CGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2981
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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