CMKLR1

CMKLR1 (Chemerin Chemokine-Like Receptor 1) is a Protein Coding gene. Diseases associated with CMKLR1 include Gerstmann Syndrome and Cataract 18. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is GPR1.

Full Name

Chemerin Chemokine-Like Receptor 1

Function

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Biological Process

Chemotaxis Source: UniProtKB
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Negative regulation of interleukin-12 production Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of fat cell differentiation Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: DFLAT
Regulation of calcium-mediated signaling Source: UniProtKB
Skeletal system development Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-41
Helical: 42-64
Cytoplasmic: 65-75
Helical: 76-97
Extracellular: 98-114
Helical: 115-135
Cytoplasmic: 136-154
Helical: 155-176
Extracellular: 177-224
Helical: 225-245
Cytoplasmic: 246-261
Helical: 262-282
Extracellular: 283-300
Helical: 301-320
Cytoplasmic: 321-373