CORO1B

Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM

coronin, actin binding protein, 1B

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

Actin cytoskeleton organization Source: CACAO
Actin filament branching Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Actin filament organization Source: GO_Central
Cell migration Source: UniProtKB
Cellular response to platelet-derived growth factor stimulus Source: UniProtKB
Endothelial cell chemotaxis Source: UniProtKB
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
Positive regulation of lamellipodium morphogenesis Source: UniProtKB
Protein localization to cell leading edge Source: UniProtKB
Regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Ruffle organization Source: UniProtKB
Wound healing Source: UniProtKB

Cytoskeleton; Stress fiber. Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.

Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.