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Mouse Anti-CORO1B Recombinant Antibody (CBFYC-2105) (V2LY-1206-LY811)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2105
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 390-489 mapping at the C-terminus of human Coronin 1B.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
coronin, actin binding protein, 1B
Entrez Gene ID
57175
UniProt ID
Q9BR76
Function
Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
Biological Process
Actin cytoskeleton organization Source: CACAO
Actin filament branching Source: UniProtKB
Actin filament bundle assembly Source: UniProtKB
Actin filament organization Source: GO_Central
Cell migration Source: UniProtKB
Cellular response to platelet-derived growth factor stimulus Source: UniProtKB
Endothelial cell chemotaxis Source: UniProtKB
Negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
Positive regulation of lamellipodium morphogenesis Source: UniProtKB
Protein localization to cell leading edge Source: UniProtKB
Regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Ruffle organization Source: UniProtKB
Wound healing Source: UniProtKB
Cellular Location
Cytoskeleton; Stress fiber. Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.
PTM
Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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