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CXCR1

CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include Human Immunodeficiency Virus Type 1 and Acute Pyelonephritis. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CXCR2.
Full Name
C-X-C Motif Chemokine Receptor 1
Function
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Receptor internalization Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-39
Helical: 40-66
Cytoplasmic: 67-75
Helical: 76-96
Extracellular: 97-111
Helical: 112-133
Cytoplasmic: 134-154
Helical: 155-174
Extracellular: 175-199
Helical: 200-220
Cytoplasmic: 221-242
Helical: 243-264
Extracellular: 265-285
Helical: 286-308
Cytoplasmic: 309-350

Anti-CXCR1 antibodies

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Mouse Anti-CXCR1 Recombinant Antibody (42705) (CBMAB-C1284-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 42705
Application*: F, IH, N, MC

Mouse Anti-CXCR1 Recombinant Antibody (501) (CBMAB-C2593-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 501
Application*: E, WB, IH, C, F

Mouse Anti-CXCR1 Recombinant Antibody (42704) (CBMAB-C6471-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 42704
Application*: F, IH

Mouse Anti-CXCR1 Recombinant Antibody (42705.111) (CBMAB-C6472-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 42705.111
Application*: F, I

Mouse Anti-CXCR1 Recombinant Antibody (5A12) (CBMAB-C7260-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5A12
Application*: F

Mouse Anti-CXCR1 Recombinant Antibody (7D22) (CBMAB-C8619-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 7D22
Application*: F, IH, N

Mouse Anti-CXCR1 Recombinant Antibody (8F1-1-4) (CBMAB-C9176-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 8F1-1-4
Application*: F, IH, P

Mouse Anti-CXCR1 Recombinant Antibody (CBYY-C0703) (CBMAB-C2084-YY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0703
Application*: F

Mouse Anti-CXCR1 Recombinant Antibody (CBYY-C2362) (CBMAB-C3800-YY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C2362
Application*: F, IH, N

Mouse Anti-CXCR1 Recombinant Antibody (14L325) (CBMAB-C3237-CN)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L325
Application*: FC, IH, N

Rat Anti-CXCR1 Recombinant Antibody (U45-632) (CBMAB-C11393-LY)

Datasheet SDS
Target: CXCR1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: U45-632
Application*: F

Mouse Anti-CXCR1 Recombinant Antibody (MM0221-7D22) (CBMAB-C11394-LY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: MM0221-7D22
Application*: C, N, F

Rabbit Anti-CXCR1 (N-terminus) Recombinant Antibody (CBFYC-0203) (CBMAB-C0228-FY)

Datasheet SDS
Target: CXCR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0203
Application*: F

Mouse Anti-CXCR1 Recombinant Antibody (CBFYC-2532) (CBMAB-C2606-FY)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYC-2532
Application*: WB, F, N

Mouse Anti-CXCR1 Recombinant Antibody (CBXC-3101) (CBMAB-C0360-CQ)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-3101
Application*: F, IH, P

Mouse Anti-CXCR1 Recombinant Antibody (CBXC-3045) (CBMAB-C0931-CQ)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXC-3045
Application*: F, IH, P, C, N, MC

Mouse Anti-CXCR1 Recombinant Antibody (CBXC-1186) (CBMAB-C1452-CQ)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1186
Application*: F

Mouse Anti-CXCR1 Recombinant Antibody (CBXC-2313) (CBMAB-C1692-CQ)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-2313
Application*: F

Mouse Anti-CXCR1 Recombinant Antibody (CBCNC-534) (CBMAB-C3238-CN)

Datasheet SDS
Target: CXCR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-534
Application*: E, FC, IH, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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