Mouse Anti-CXCR1 Recombinant Antibody (CBXC-2313) (V2LY-0125-LY765)

Name: Mouse Anti-CXCR1 Recombinant Antibody (CBXC-2313)
SKU: V2LY-0125-LY765
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXC-2313

Antibody Isotype

IgG2a

Application

FC, Neutralization

Basic Information

Immunogen

Human CXCR1/IL-8 RA, Met1-Leu350.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
FC	0.25 μg/10⁶ cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

C-X-C Motif Chemokine Receptor 1

Entrez Gene ID

3577

UniProt ID

P25024

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: UniProtKB
Dendritic cell chemotaxis Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Receptor internalization Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-39
Helical: 40-66
Cytoplasmic: 67-75
Helical: 76-96
Extracellular: 97-111
Helical: 112-133
Cytoplasmic: 134-154
Helical: 155-174
Extracellular: 175-199
Helical: 200-220
Cytoplasmic: 221-242
Helical: 243-264
Extracellular: 265-285
Helical: 286-308
Cytoplasmic: 309-350

More Infomation

References

Zhao, B., Diao, J., Li, L., Kondo, H., Li, L., & Hirono, I. (2021). Molecular characterization and expression analysis of Japanese flounder (Paralichthys olivaceus) chemokine receptor CXCR2 in comparison with CXCR1. Developmental & Comparative Immunology, 120, 104047.

Ren, J., Xu, N., Zhou, R., Huang, F., Zhang, H., & Li, W. (2021). Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p/CXC motif chemokine receptor 1 axis. Bioengineered, 12(1), 6083-6095.

Kharche, S., Joshi, M., Chattopadhyay, A., & Sengupta, D. (2021). Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1. PLoS computational biology, 17(5), e1008593.

Wang, C., Li, Q., Yang, H., Gao, C., Du, Q., Zhang, C., ... & Li, Q. (2020). MMP9, CXCR1, TLR6, and MPO participant in the progression of coronary artery disease. Journal of Cellular Physiology, 235(11), 8283-8292.

Hosoki, K., Rajarathnam, K., & Sur, S. (2019). Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology, 49(1), 130.

Cao, Y., Liu, H., Zhang, H., Lin, C., Li, R., Wu, S., ... & Xu, J. (2017). CXC chemokine receptor 1 predicts postoperative prognosis and chemotherapeutic benefits for TNM II and III resectable gastric cancer patients. Oncotarget, 8(12), 20328.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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