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DIAPH2

The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Full Name

Diaphanous Related Formin 2

Function

Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.

Biological Process

Actin filament organization Source: InterPro
Female gamete generation Source: ProtInc
Oogenesis Source: UniProtKB-KW

Cellular Location

Isoform 3: Cytosol; Early endosome. Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

Involvement in disease

Premature ovarian failure 2A (POF2A):
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.

Anti-DIAPH2 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-DIAPH2 Recombinant Antibody (D3) (CBMAB-AP1870LY)

SDS

Target: DIAPH2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: D3

Application*: ELISA, IHC, WB

Mouse Anti-DIAPH2 Recombinant Antibody (356) (CBMAB-XB0356-YC)

SDS

Target: DIAPH2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat, Cattle, Chicken

Clone: 356

Application*: WB, IP, IF, E

Mouse Anti-DIAPH2 Recombinant Antibody (12K79) (CBMAB-D0889-YC)

SDS

Target: DIAPH2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: 12K79

Application*: WB, IP, IF, E, P

Mouse Anti-DIAPH2 Recombinant Antibody (V78P3C10/D3) (CBMAB-D0887-YC)

SDS

Target: DIAPH2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V78P3C10/D3

Application*: WB, E, IH

Mouse Anti-DIAPH2 Recombinant Antibody (CL1111) (CBMAB-D0885-YC)

SDS

Target: DIAPH2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CL1111

Application*: IH, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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