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Mouse Anti-DIAPH2 Recombinant Antibody (12K79) (CBMAB-D0889-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
12K79
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 23-110 mapping near the N-terminus of human Dia 2.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 314-540

Target

Full Name
Diaphanous Related Formin 2
Introduction
DIAPH2 belongs to the diaphanous subfamily of the formin homology family of proteins. DIAPH2 may play a role in the development and normal function of the ovaries. Defects in DIAPH2 have been linked to premature ovarian failure 2.
Entrez Gene ID
1730
UniProt ID
O60879
Alternative Names
Diaphanous Related Formin 2; DRF2; DIA; Diaphanous (Drosophila, Homolog) 2; Diaphanous Homolog 2 (Drosophila); Protein Diaphanous Homolog 2; Diaphanous-Related Formin-2;
Function
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
Biological Process
Actin filament organization Source: InterPro
Female gamete generation Source: ProtInc
Oogenesis Source: UniProtKB-KW
Cellular Location
Isoform 3: Cytosol; Early endosome. Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
Involvement in disease
Premature ovarian failure 2A (POF2A):
An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
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For research use only. Not intended for any clinical use.

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