DOCK4

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq]

dedicator of cytokinesis 4

Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467).

Involved in regulation of adherens junction between cells (PubMed:12628187).

Plays a role in cell migration (PubMed:20679435).

Isoform 2:
Has a higher guanine nucleotide exchange factor activity compared to other isoforms.

Cell chemotaxis Source: UniProtKB
Negative regulation of vascular associated smooth muscle contraction Source: BHF-UCL
Positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
Small GTPase mediated signal transduction Source: InterPro

Cell membrane; Cytosol; Cell projection. Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells.