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DPYSL2

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Full Name

Dihydropyrimidinase Like 2

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Biological Process

Axon guidance Source: InterPro
Brain development Source: InterPro
Cytoskeleton organization Source: UniProtKB
Endocytosis Source: UniProtKB
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc
Regulation of axon extension Source: InterPro
Regulation of neuron differentiation Source: InterPro
Signal transduction Source: ProtInc

Cellular Location

Cytoskeleton; Cytosol; Membrane. Tightly but non-covalently associated with membranes.

PTM

3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.

Anti-DPYSL2 antibodies

Mouse Anti-DPYSL2 Recombinant Antibody (CBYY-C2866) (CBMAB-C4308-YY)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG3

Specificity: Mouse, rat

Clone: CBYY-C2866

Application*: IH, WB

Rabbit Anti-DPYSL2 Recombinant Antibody (D8L6V) (CBMAB-C3358-CN)

SDS

Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D8L6V

Application*: WB, IP, IF

Recombinant Mouse Anti-DPYSL2 Antibody (CBAb087) (CBMAB-Ab087-LY)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBAb087

Application*: WB

Mouse Anti-DPYSL2 Recombinant Antibody (CAP649) (CBMAB-AP1943LY)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CAP649

Application*: WB

Rabbit Anti-DPYSL2 Recombinant Antibody (EG832) (CBMAB-EN991-LY)

SDS

Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG832

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Mouse Anti-DPYSL2 Monoclonal Antibody (Y14C) (CBMAB-1060-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: Y14C

Application*: E, P, WB

Mouse Anti-DPYSL2 Monoclonal Antibody (M539) (CBMAB-1729-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: M539

Application*: WB

Mouse Anti-DPYSL2 Recombinant Antibody (3F4) (CBMAB-D1649-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: 3F4

Application*: IH, WB

Mouse Anti-DPYSL2 Recombinant Antibody (C4G) (CBMAB-D1650-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: C4G

Application*: WB, IP

Mouse Anti-DPYSL2 Recombinant Antibody (N3E) (CBMAB-D1651-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: N3E

Application*: WB

Mouse Anti-DPYSL2 Recombinant Antibody (CBYCD-399) (CBMAB-D1652-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: CBYCD-399

Application*: E, WB, P

Mouse Anti-DPYSL2 Recombinant Antibody (10i33) (CBMAB-D1653-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 10i33

Application*: E, WB

Mouse Anti-DPYSL2 Recombinant Antibody (33CT11.40.3) (CBMAB-D1654-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: 33CT11.40.3

Application*: WB, E

Mouse Anti-DPYSL2 Recombinant Antibody (1F11) (CBMAB-D1655-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1F11

Application*: E, IF, WB

Rabbit Anti-DPYSL2 Recombinant Antibody (CBYCD-400) (CBMAB-D1656-YC)

SDS

Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCD-400

Application*: F, IC, P, IP, WB

Mouse Anti-DPYSL2 Recombinant Antibody (CBFYC-2595) (CBMAB-C2669-FY)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat, Human

Clone: CBFYC-2595

Application*: WB, P, F

Rabbit Anti-DPYSL2 Recombinant Antibody (CBWJC-2115) (CBMAB-C2821WJ)

SDS

Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-2115

Application*: WB, IP, P, F, IC

Mouse Anti-DPYSL2 Recombinant Antibody (CBWJC-3593) (CBMAB-C4832WJ)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat

Clone: CBWJC-3593

Application*: WB, IP

Mouse Anti-DPYSL2 Recombinant Antibody (CBWJC-3595) (CBMAB-C4834WJ)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse

Clone: CBWJC-3595

Application*: WB, E

Rabbit Anti-DPYSL2 Recombinant Antibody (EPR7792) (CBMAB-1524-CN)

SDS

Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EPR7792

Application*: F, IF, P, IP, WB

Rabbit Anti-DPYSL2 Recombinant Antibody (EPR7876) (CBMAB-1525-CN)

SDS

Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EPR7876

Application*: WB

Mouse Anti-DPYSL2 Monoclonal Antibody (1B1) (CBMAB-0974-YC)

SDS

Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: 1B1

Application*: F, P, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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