DPYSL2

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Full Name

Dihydropyrimidinase Like 2

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

Biological Process

Axon guidance Source: InterPro
Brain development Source: InterPro
Cytoskeleton organization Source: UniProtKB
Endocytosis Source: UniProtKB
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc
Regulation of axon extension Source: InterPro
Regulation of neuron differentiation Source: InterPro
Signal transduction Source: ProtInc

Cellular Location

Cytoskeleton; Cytosol; Membrane. Tightly but non-covalently associated with membranes.

PTM

3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.

Anti-DPYSL2 antibodies

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Mouse Anti-DPYSL2 Recombinant Antibody (CBWJC-3595) (CBMAB-C4834WJ)

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Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBWJC-3595

Application*: WB

Datasheet SDS

Mouse Anti-DPYSL2 Recombinant Antibody (1061) (CBMAB-1729-YC)

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Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 1061

Application*: WB, IP, IF, P

Datasheet SDS

Mouse Anti-DPYSL2 Recombinant Antibody (1060) (CBMAB-1060-YC)

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Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 1060

Application*: WB

Datasheet SDS

Mouse Dpysl2 ELISA Kit (2) (V2LY-0626-LY1915)

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Target: Dpysl2

Sensitivity: 0.0095 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Datasheet SDS

Mouse Dpysl2 ELISA Kit (V2LY-0626-LY1824)

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Target: Dpysl2

Sensitivity: 0.04 ng/mL

Detection Range: 0.1-40 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Datasheet SDS

Rat Dpysl2 ELISA Kit (V2LY-0626-LY1467)

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Target: Dpysl2

Sensitivity: 0.053 ng/mL

Detection Range: 0.1-40 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Rat

Assay Type: Sandwich

Reactivity: Rat

Datasheet SDS

Human Recombinant DPYSL2 protein, GST Tag (V2LY-0526-LY3637)

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Target: DPYSL2

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

Datasheet SDS

Rabbit Anti-DPYSL2 Recombinant Antibody (
1A1) (V2LY-0725-LY1302)

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Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 1A1

Application*: E, IH

Datasheet SDS

Rabbit Anti-DPYSL2 Recombinant Antibody (
20D8) (V2LY-0725-LY915)

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Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 20D8

Application*: E, IH, IF, F

Datasheet SDS

Rabbit Anti-DPYSL2 Recombinant Antibody (CBWJC-2115) (V2LY-0425-LY898)

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Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-2115

Application*: WB, IP, IH, F, IF

Datasheet SDS

Mouse Anti-DPYSL2 Recombinant Antibody (1F11) (V2LY-0425-LY896)

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Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: 1F11

Application*: E, IF, WB

Datasheet SDS

Rabbit Anti-DPYSL2 (Phospho-T514) Recombinant Antibody (1524) (V2LY-0425-LY894)

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Target: DPYSL2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 1524

Application*: WB

Datasheet SDS

Mouse Anti-DPYSL2 Recombinant Antibody (D1654) (CBMAB-D1654-YC)

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Target: DPYSL2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig, Chicken

Clone: D1654

Application*: WB, IP, IF, E, P

Datasheet SDS

More Infomation

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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