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Mouse Anti-DPYSL2 Recombinant Antibody (1061) (CBMAB-1729-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1061
Antibody Isotype
IgG2a
Application
WB, IP, IF, IHC-P

Basic Information

Immunogen
C-terminus of human CRMP-2.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.1 mg/ml
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dihydropyrimidinase Like 2
Introduction
Dihydropyrimidinase like 2 (DPYSL2) is a member of the collapsin response mediator protein family. DPYSL2 promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. DPYSL2 has been implicated in multiple neurological disorders, and may play a key role in the development of Alzheimer's disease.
Entrez Gene ID
Human1808
Mouse12934
Rat25416
UniProt ID
HumanQ16555
MouseO08553
RatP47942
Alternative Names
DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
Function
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Biological Process
Axon guidance Source: InterPro
Brain development Source: InterPro
Cytoskeleton organization Source: UniProtKB
Endocytosis Source: UniProtKB
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc
Regulation of axon extension Source: InterPro
Regulation of neuron differentiation Source: InterPro
Signal transduction Source: ProtInc
Cellular Location
Cytoskeleton; Cytosol; Membrane. Tightly but non-covalently associated with membranes.
PTM
3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
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For research use only. Not intended for any clinical use.

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