EHD1

EHD1 belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. It-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. EHD1 is thought to function in the endocytosis of IGF1 receptors.

EH Domain Containing 1

ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528).

Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876).

Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity).

Plays a role in myoblast fusion (By similarity).

Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity).

Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250).

Cellular response to nerve growth factor stimulus Source: UniProtKB
Cholesterol homeostasis Source: BHF-UCL
Cilium assembly Source: UniProtKB
Endocytic recycling Source: UniProtKB
Endocytosis Source: UniProtKB
Endosomal transport Source: GO_Central
Intracellular protein transport Source: UniProtKB
Low-density lipoprotein particle clearance Source: BHF-UCL
Neuron projection development Source: UniProtKB
Positive regulation of cholesterol storage Source: BHF-UCL
Positive regulation of endocytic recycling Source: UniProtKB
Positive regulation of myoblast fusion Source: UniProtKB
Positive regulation of neuron projection development Source: Ensembl
Protein homooligomerization Source: UniProtKB
Protein localization to cilium Source: UniProtKB
Protein localization to plasma membrane Source: GO_Central

Cell membrane; Cilium membrane; Recycling endosome membrane; Early endosome membrane. Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity).