ELMO1

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Engulfment And Cell Motility 1

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Actin cytoskeleton organization Source: UniProtKB
Actin filament organization Source: GO_Central
Apoptotic process Source: UniProtKB
Cell migration Source: InterPro
Cell motility Source: UniProtKB
Phagocytosis, engulfment Source: UniProtKB
Rac protein signal transduction Source: UniProtKB
Regulation of catalytic activity Source: GOC

Cell membrane; Cytoplasm. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.

Phosphorylated by HCK.