Sign in or Register   Sign in or Register
  |  

Rabbit Anti-ELMO1 Recombinant Antibody (CBFYE-0139) (CBMAB-E0302-FY)

This product is rabbit antibody that recognizes ELMO1. The antibody CBFYE-0139 can be used for immunoassay techniques such as: WB, IP, IF.
See all ELMO1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBFYE-0139
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Engulfment And Cell Motility 1
Introduction
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human9844
Mouse140580
Rat361251
UniProt ID
HumanQ92556
MouseQ8BPU7
RatD3ZY46
Alternative Names
Engulfment And Cell Motility 1; Engulfment And Cell Motility 1; Engulfment And Cell Motility Protein 1; Protein Ced-12 Homolog; Ced-12 Homolog 1; KIAA0281; CED-12; ELMO-1; CED12
Research Area
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament organization Source: GO_Central
Apoptotic process Source: UniProtKB
Cell migration Source: InterPro
Cell motility Source: UniProtKB
Phagocytosis, engulfment Source: UniProtKB
Rac protein signal transduction Source: UniProtKB
Regulation of catalytic activity Source: GOC
Cellular Location
Cell membrane; Cytoplasm. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
PTM
Phosphorylated by HCK.

Tocci, S., Ibeawuchi, S. R., Das, S., & Sayed, I. M. (2022). Role of ELMO1 in inflammation and cancer—clinical implications. Cellular Oncology, 1-21.

Kohorn, B. D., Zorensky, F. D., Dexter-Meldrum, J., Chabout, S., Mouille, G., & Kohorn, S. (2021). Mutation of an Arabidopsis Golgi membrane protein ELMO1 reduces cell adhesion. Development, 148(10), dev199420.

Arandjelovic, S., Perry, J. S., Zhou, M., Ceroi, A., Smirnov, I., Walk, S. F., ... & Ravichandran, K. S. (2021). ELMO1 signaling is a promoter of osteoclast function and bone loss. Nature communications, 12(1), 1-12.

Kukimoto-Niino, M., Katsura, K., Kaushik, R., Ehara, H., Yokoyama, T., Uchikubo-Kamo, T., ... & Shirouzu, M. (2021). Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex. Science Advances, 7(30), eabg3147.

Xie, Z., Yu, W., Zheng, G., Li, J., Cen, S., Ye, G., ... & Shen, H. (2021). TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis. Nature communications, 12(1), 1-14.

Chang, L., Yang, J., Jo, C. H., Boland, A., Zhang, Z., McLaughlin, S. H., ... & Barford, D. (2020). Structure of the DOCK2− ELMO1 complex provides insights into regulation of the auto-inhibited state. Nature communications, 11(1), 1-17.

Arandjelovic, S., Perry, J. S., Lucas, C. D., Penberthy, K. K., Kim, T. H., Zhou, M., ... & Ravichandran, K. S. (2019). A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis. Nature immunology, 20(2), 141-151.

Peng, H., Zhang, Y., Zhou, Z., Guo, Y., Huang, X., Westover, K. D., ... & Shen, S. (2019). Intergrated analysis of ELMO1, serves as a link between tumour mutation burden and epithelial-mesenchymal transition in hepatocellular carcinoma. EBioMedicine, 46, 105-118.

Luo, T., Chen, M., Zhao, Y., Wang, D., Liu, J., Chen, J., ... & Li, L. (2019). Macrophage-associated lncRNA ELMO1-AS1: a novel therapeutic target and prognostic biomarker for hepatocellular carcinoma. OncoTargets and therapy, 12, 6203.

Li, W., Tam, K. M. V., Chan, W. W. R., Koon, A. C., Ngo, J. C. K., Chan, H. Y. E., & Lau, K. F. (2018). Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. Journal of Biological Chemistry, 293(20), 7674-7688.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-ELMO1 Recombinant Antibody (CBFYE-0139)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare