ELMO2

The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]

Full Name

engulfment and cell motility 2

Research Area

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Biological Process

Actin filament organization Source: GO_Central
Apoptotic process Source: UniProtKB-KW
Cell-cell adhesion Source: InterPro
Cell chemotaxis Source: UniProtKB
Cell motility Source: GO_Central
Phagocytosis Source: UniProtKB-KW

Cellular Location

Cytoplasm; Cytosol; Membrane

Involvement in disease

Vascular malformation, primary intraosseous (VMOS):
A rare malformation characterized by non-neoplastic severe expansions of blood vessels, usually seen in the vertebral column and in the skull. The most commonly affected bones in the skull are the mandible and the maxilla, and life-threatening bleeding after a simple tooth extraction is frequently observed. Inheritance is autosomal recessive.

Anti-ELMO2 antibodies

Mouse Anti-ELMO2 Recombinant Antibody (CBFYE-0794) (CBMAB-E1241-FY)

Datasheet

SDS

Target: ELMO2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYE-0794

Application*: E, EC

Mouse Anti-ELMO2 (AA 89-188) Recombinant Antibody (CBFYE-0793) (CBMAB-E1240-FY)

Datasheet

SDS

Target: ELMO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYE-0793

Application*: E

Rabbit Anti-ELMO2 Recombinant Antibody (CBFYE-0792) (CBMAB-E1239-FY)

Datasheet

SDS

Target: ELMO2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBFYE-0792

Application*: WB

Mouse Anti-ELMO2 Recombinant Antibody (CBFYE-0201) (CBMAB-E0446-FY)

Datasheet

SDS

Target: ELMO2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYE-0201

Application*: E, WB

Mouse Anti-ELMO2 Recombinant Antibody (3G7) (CBMAB-A2578-LY)

Datasheet

SDS

Target: ELMO2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G7

Application*: E, E

Mouse Anti-ELMO2 Recombinant Antibody (2E5) (CBMAB-A2577-LY)

Datasheet

SDS

Target: ELMO2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2E5

Application*: SE, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)