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Mouse Anti-ELMO2 Recombinant Antibody (CBFYE-0201) (CBMAB-E0446-FY)

This product is mouse antibody that recognizes ELMO2. The antibody CBFYE-0201 can be used for immunoassay techniques such as: ELISA, WB.
See all ELMO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0201
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant from human ELMO2 with GST tag MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
engulfment and cell motility 2
Introduction
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
63916
UniProt ID
Q96JJ3
Alternative Names
Engulfment And Cell Motility 2; Protein Ced-12 Homolog A; Engulfment And Cell Motility 2; Engulfment And Cell Motility Protein 2; PH Domain Protein CED12A; Ced-12 Homolog 2; KIAA1834; HCed-12A
Research Area
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Biological Process
Actin filament organization Source: GO_Central
Apoptotic process Source: UniProtKB-KW
Cell-cell adhesion Source: InterPro
Cell chemotaxis Source: UniProtKB
Cell motility Source: GO_Central
Phagocytosis Source: UniProtKB-KW
Cellular Location
Cytoplasm; Cytosol; Membrane
Involvement in disease
Vascular malformation, primary intraosseous (VMOS):
A rare malformation characterized by non-neoplastic severe expansions of blood vessels, usually seen in the vertebral column and in the skull. The most commonly affected bones in the skull are the mandible and the maxilla, and life-threatening bleeding after a simple tooth extraction is frequently observed. Inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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