ELOVL6

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

ELOVL Fatty Acid Elongase 6

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Fatty acid elongation, monounsaturated fatty acid Source: GO_Central
Fatty acid elongation, polyunsaturated fatty acid Source: GO_Central
Fatty acid elongation, saturated fatty acid Source: UniProtKB
Long-chain fatty acid biosynthetic process Source: UniProtKB
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Sphingolipid biosynthetic process Source: GO_Central
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: GO_Central

Endoplasmic reticulum membrane

N-glycosylated.