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Rabbit Anti-ELOVL6 Recombinant Antibody (EG1099) (CBMAB-EN1295-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1099
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ELOVL6.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ELOVL Fatty Acid Elongase 6
Introduction
Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
Human79071
Mouse170439
Rat171402
UniProt ID
HumanQ9H5J4
MouseQ920L5
RatQ920L6
Alternative Names
ELOVL Fatty Acid Elongase 6; ELOVL Family Member 6, Elongation Of Long Chain Fatty Acids (FEN1/Elo2, SUR4/Elo3-Like, Yeast); Very Long Chain 3-Ketoacyl-CoA Synthase 6; Very Long Chain 3-Oxoacyl-CoA Synthase 6; 3-Keto Acyl-CoA Synthase ELOVL6; Long-Chain Fatty-Acyl Elongase; Fatty Acyl-CoA Elongase; Fatty Acid Elongase 2;
Research Area
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Biological Process
Fatty acid elongation, monounsaturated fatty acid Source: GO_Central
Fatty acid elongation, polyunsaturated fatty acid Source: GO_Central
Fatty acid elongation, saturated fatty acid Source: UniProtKB
Long-chain fatty acid biosynthetic process Source: UniProtKB
Long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Sphingolipid biosynthetic process Source: GO_Central
Unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
Very long-chain fatty acid biosynthetic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane
PTM
N-glycosylated.
More Infomation

He, Q., Luo, J., Wu, J., Li, Z., Yao, W., Zang, S., & Niu, H. (2021). ELOVL6 promoter binding sites directly targeted by sterol regulatory element binding protein 1 in fatty acid synthesis of goat mammary epithelial cells. Journal of Dairy Science, 104(5), 6253-6266.

Matsuzaka, T. (2021). Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes. Diabetology international, 12(1), 68-73.

Tian, X., Li, S., & Ge, G. (2021). Apatinib promotes ferroptosis in colorectal cancer cells by targeting ELOVL6/ACSL4 signaling. Cancer Management and Research, 13, 1333.

Junjvlieke, Z., Khan, R., Mei, C., Cheng, G., Wang, S., Raza, S. H. A., ... & Zan, L. (2020). Effect of ELOVL6 on the lipid metabolism of bovine adipocytes. Genomics, 112(3), 2282-2290.

Ting, S. Y., Janaranjani, M., Merosha, P., Sam, K. K., Wong, S. C., Goh, P. T., ... & Chong Shu-Chien, A. (2020). Two elongases, Elovl4 and Elovl6, fulfill the elongation routes of the LC-PUFA biosynthesis pathway in the orange mud crab (Scylla olivacea). Journal of agricultural and food chemistry, 68(14), 4116-4130.

Weiss-Hersh, K., Garcia, A. L., Marosvölgyi, T., Szklenár, M., Decsi, T., & Rühl, R. (2020). Saturated and monounsaturated fatty acids in membranes are determined by the gene expression of their metabolizing enzymes SCD1 and ELOVL6 regulated by the intake of dietary fat. European Journal of Nutrition, 59(6), 2759-2769.

Wang, X., Sun, S., Cao, X., & Gao, J. (2020). Quantitative phosphoproteomic analysis reveals the regulatory networks of Elovl6 on lipid and glucose metabolism in zebrafish. International journal of molecular sciences, 21(8), 2860.

Li, Y., Pang, Y., Xiang, X., Du, J., Mai, K., & Ai, Q. (2019). Molecular cloning, characterization, and nutritional regulation of Elovl6 in large yellow croaker (Larimichthys crocea). International journal of molecular sciences, 20(7), 1801.

Li, H., Wang, X., Tang, J., Zhao, H., & Duan, M. (2019). Decreased expression levels of ELOVL6 indicate poor prognosis in hepatocellular carcinoma. Oncology letters, 18(6), 6214-6220.

Su, Y. C., Feng, Y. H., Wu, H. T., Huang, Y. S., Tung, C. L., Wu, P., ... & Wu, C. L. (2018). Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression. Scientific reports, 8(1), 1-8.

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For research use only. Not intended for any clinical use.

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