ENA

Enabled is the sole Drosophila member of the Ena/VASP family. It acts as a processive actin polymerase, stimulating actin addition at the barbed end. It has roles in both epithelial morphogenesis and CNS pathfinding. It functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline.

Ena

Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics.

Actin cytoskeleton organization Source: FlyBase
Actin filament organization Source: FlyBase
Axon guidance Source: FlyBase
Axonogenesis Source: FlyBase
Border follicle cell migration Source: FlyBase
Compound eye development Source: FlyBase
Cytoplasmic transport, nurse cell to oocyte Source: FlyBase
Dendrite morphogenesis Source: FlyBase
Dorsal closure Source: FlyBase
Epithelial cell morphogenesis Source: FlyBase
Filopodium assembly Source: FlyBase
Formation of a compartment boundary Source: FlyBase
Germ-band shortening Source: FlyBase
Gonad morphogenesis Source: FlyBase
Head involution Source: FlyBase
Negative regulation of synaptic assembly at neuromuscular junction Source: FlyBase
Positive regulation of cell migration Source: FlyBase
Positive regulation of cell projection organization Source: FlyBase
Positive regulation of filopodium assembly Source: FlyBase
Regulation of actin cytoskeleton organization Source: FlyBase
Regulation of filopodium assembly Source: FlyBase
Regulation of lamellipodium assembly Source: FlyBase
Subsynaptic reticulum organization Source: FlyBase
Suture of dorsal opening Source: FlyBase

Cytoskeleton; Lamellipodium. Expressed at the leading edge of lamellipodia. Colocalizes with chic at the periphery of cells.

Tyrosine phosphorylated on multiple sites by Abl kinase. In vitro, phosphorylation on specific tyrosine residues inhibits interaction with Abl and Src SH3 domains.