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Mouse Anti-ENA Recombinant Antibody (5G2) (CBMAB-0257-CN)

This product is a mouse antibody that recognizes ENA of Drosophila. The antibody 5G2 can be used for immunoassay techniques such as: IF, IP, WB.
See all ENA antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
5G2
Antibody Isotype
IgG1
Application
IF, IP, WB

Basic Information

Immunogen
Enabled (aa. 105-370) fusion protein tagged with 6X-HIS.
Specificity
Common fruit fly
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ena
Introduction
Enabled is the sole Drosophila member of the Ena/VASP family. It acts as a processive actin polymerase, stimulating actin addition at the barbed end. It has roles in both epithelial morphogenesis and CNS pathfinding. It functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline.
Entrez Gene ID
37201
UniProt ID
Q8T4F7
Alternative Names
CG15112; Dmel\CG15112; Ena; ENA/VASP; enb; Enb; l(2)02029; Vasp; VASP
Research Area
Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics.
Biological Process
Actin cytoskeleton organization Source: FlyBase
Actin filament organization Source: FlyBase
Axon guidance Source: FlyBase
Axonogenesis Source: FlyBase
Border follicle cell migration Source: FlyBase
Compound eye development Source: FlyBase
Cytoplasmic transport, nurse cell to oocyte Source: FlyBase
Dendrite morphogenesis Source: FlyBase
Dorsal closure Source: FlyBase
Epithelial cell morphogenesis Source: FlyBase
Filopodium assembly Source: FlyBase
Formation of a compartment boundary Source: FlyBase
Germ-band shortening Source: FlyBase
Gonad morphogenesis Source: FlyBase
Head involution Source: FlyBase
Negative regulation of synaptic assembly at neuromuscular junction Source: FlyBase
Positive regulation of cell migration Source: FlyBase
Positive regulation of cell projection organization Source: FlyBase
Positive regulation of filopodium assembly Source: FlyBase
Regulation of actin cytoskeleton organization Source: FlyBase
Regulation of filopodium assembly Source: FlyBase
Regulation of lamellipodium assembly Source: FlyBase
Subsynaptic reticulum organization Source: FlyBase
Suture of dorsal opening Source: FlyBase
Cellular Location
Cytoskeleton; Lamellipodium. Expressed at the leading edge of lamellipodia. Colocalizes with chic at the periphery of cells.
PTM
Tyrosine phosphorylated on multiple sites by Abl kinase. In vitro, phosphorylation on specific tyrosine residues inhibits interaction with Abl and Src SH3 domains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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