ENY2

ENY2 (ENY2, Transcription And Export Complex 2 Subunit) is a Protein Coding gene. Diseases associated with ENY2 include Warsaw Breakage Syndrome. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor transcription coactivator activity.

Eny2, Transcription And Export Complex 2 Subunit

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879).

As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).

Histone deubiquitination Source: UniProtKB
Negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Poly(A)+ mRNA export from nucleus Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription elongation from RNA polymerase II promoter Source: UniProtKB-UniRule

Nucleoplasm. Localization at the nuclear pore complex requires NUP153 and TPR.