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Mouse Anti-ENY2 Recombinant Antibody (CBFYE-0913) (CBMAB-E1385-FY)

This product is mouse antibody that recognizes ENY2. The antibody CBFYE-0913 can be used for immunoassay techniques such as: WB, IHC, IF, IHC-P.
See all ENY2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBFYE-0913
Antibody Isotype
IgG1
Application
WB, IHC, IF, IHC-P

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human ENY2
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Center

Target

Full Name
Eny2, Transcription And Export Complex 2 Subunit
Introduction
ENY2 (ENY2, Transcription And Export Complex 2 Subunit) is a Protein Coding gene. Diseases associated with ENY2 include Warsaw Breakage Syndrome. Among its related pathways are Chromatin organization.
Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor transcription coactivator activity.
Entrez Gene ID
Human56943
Rat685258
UniProt ID
HumanQ9NPA8
RatD3ZWF5
Alternative Names
ENY2, Transcription And Export Complex 2 Subunit; Enhancer Of Yellow 2 Transcription Factor Homolog; Enhancer Of Yellow 2 Homolog (Drosophila); Transcription And MRNA Export Factor ENY2; Enhancer Of Yellow 2 Homolog; E(Y)2; Sus1; DC6
Research Area
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879).

As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).
Biological Process
Histone deubiquitination Source: UniProtKB
Negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Poly(A)+ mRNA export from nucleus Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription elongation from RNA polymerase II promoter Source: UniProtKB-UniRule
Cellular Location
Nucleoplasm. Localization at the nuclear pore complex requires NUP153 and TPR.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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