ERN2

ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ERN1.

Endoplasmic Reticulum To Nucleus Signaling 2

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Apoptotic chromosome condensation Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: GO_Central
IRE1-mediated unfolded protein response Source: GO_Central
mRNA processing Source: InterPro
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of JUN kinase activity Source: Ensembl
Protein phosphorylation Source: UniProtKB
Regulation of cell cycle Source: Ensembl
Response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
rRNA catabolic process Source: UniProtKB

Endoplasmic reticulum membrane

Lumenal: 35-430
Helical: 431-451
Cytoplasmic: 452-926

Autophosphorylated.