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Rabbit Anti-ERN2 Recombinant Antibody (EG1142) (CBMAB-EN1362-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1142
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ERN2.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Endoplasmic Reticulum To Nucleus Signaling 2
Introduction
ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ERN1.
Entrez Gene ID
Human10595
Mouse26918
UniProt ID
HumanQ76MJ5
MouseQ9Z2E3
Alternative Names
Endoplasmic Reticulum To Nucleus Signaling 2; Inositol-Requiring Protein 2; ER To Nucleus Signalling 2; IRE1-BETA; HIRE2p; IRE1b; Serine/Threonine-Protein Kinase/Endoribonuclease IRE2; Endoplasmic Reticulum To Nucleus Signalling 2;
Research Area
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Biological Process
Apoptotic chromosome condensation Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: GO_Central
IRE1-mediated unfolded protein response Source: GO_Central
mRNA processing Source: InterPro
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of JUN kinase activity Source: Ensembl
Protein phosphorylation Source: UniProtKB
Regulation of cell cycle Source: Ensembl
Response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
rRNA catabolic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 35-430
Helical: 431-451
Cytoplasmic: 452-926
PTM
Autophosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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