ERP29

This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Endoplasmic Reticulum Protein 29

Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.

Intracellular protein transport Source: ParkinsonsUK-UCL
Negative regulation of gene expression Source: ParkinsonsUK-UCL
Negative regulation of protein secretion Source: ParkinsonsUK-UCL
Positive regulation of gene expression Source: ParkinsonsUK-UCL
Positive regulation of MAP kinase activity Source: ParkinsonsUK-UCL
Positive regulation of protein phosphorylation Source: ParkinsonsUK-UCL
Protein folding Source: ParkinsonsUK-UCL
Protein secretion Source: InterPro
Protein unfolding Source: ParkinsonsUK-UCL
Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl

Endoplasmic reticulum lumen; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.