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Mouse Anti-ERP29 (AA 33-261) Recombinant Antibody (CBFYE-1206) (CBMAB-E1776-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1206
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to fragment ERp31
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 33-261

Target

Full Name
Endoplasmic Reticulum Protein 29
Introduction
This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
10961
UniProt ID
P30040
Alternative Names
Endoplasmic Reticulum Protein 29; Protein Disulfide Isomerase Family A, Member 9; Endoplasmic Reticulum Resident Protein 28; Endoplasmic Reticulum Resident Protein 31; C12orf8; ERp28; ERp31; Endoplasmic Reticulum Lumenal Protein ERp28
Research Area
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
Biological Process
Intracellular protein transport Source: ParkinsonsUK-UCL
Negative regulation of gene expression Source: ParkinsonsUK-UCL
Negative regulation of protein secretion Source: ParkinsonsUK-UCL
Positive regulation of gene expression Source: ParkinsonsUK-UCL
Positive regulation of MAP kinase activity Source: ParkinsonsUK-UCL
Positive regulation of protein phosphorylation Source: ParkinsonsUK-UCL
Protein folding Source: ParkinsonsUK-UCL
Protein secretion Source: InterPro
Protein unfolding Source: ParkinsonsUK-UCL
Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
Cellular Location
Endoplasmic reticulum lumen; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
More Infomation

Bai, X., Xiong, L. L., Fang, C. L., Zhou, H. L., Xue, L. L., Hu, Y., ... & Yang, S. J. (2021). Interleukin 10 plays an important role in neonatal rats with hypoxic-ischemia associated with B-cell lymphoma 2 and endoplasmic reticulum protein 29. Analytical Cellular Pathology, 2021.

Nakao, H., Seko, A., Ito, Y., & Sakono, M. (2021). Dimerization of ER-resident molecular chaperones mediated by ERp29. Biochemical and Biophysical Research Communications, 536, 52-58.

Zou, S., Dong, R., Zou, P., Meng, X., Zhang, T., Luo, L., ... & Han, F. (2020). ERp29 affects the migratory and invasive ability of human extravillous trophoblast HTR‐8/SVneo cells via modulating the epithelial‐mesenchymal transition. Journal of Biochemical and Molecular Toxicology, 34(4), e22454.

Li, X., Cheng, T., He, Y., Zhou, S., Wang, Y., Zhang, K., & Yu, P. (2019). High glucose regulates ERp29 in hepatocellular carcinoma by LncRNA MEG3-miRNA 483-3p pathway. Life sciences, 232, 116602.

Ye, W., Li, Z., Tang, T., Du, J., Zhou, X., Wu, H., ... & Qin, G. (2019). ERp29 downregulation enhances lung adenocarcinoma cell chemosensitivity to gemcitabine by upregulating HSP27 phosphorylation. Experimental and Therapeutic Medicine, 17(1), 817-823.

Chaiyawat, P., Pruksakorn, D., Pipatwattana, P., Phanphaisarn, A., Teeyakasem, P., Klangjorhor, J., & Settakorn, J. (2019). Endoplasmic reticulum protein 29 (ERp29) as a novel prognostic marker and tumor suppressor in osteosarcoma. Journal of Bone Oncology, 16, 100233.

Guo, L., Ma, L., Liu, C., Lei, Y., Tang, N., Huang, Y., ... & Deng, Y. (2019). ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer. Oncology Reports, 41(3), 1603-1615.

McLaughlin, T., Falkowski, M., Wang, J. J., & Zhang, S. X. (2018). Molecular chaperone ERp29: a potential target for cellular protection in retinal and neurodegenerative diseases. Retinal Degenerative Diseases, 421-427.

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For research use only. Not intended for any clinical use.

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