ETV3

ETV3 (ETS Variant 3) is a Protein Coding gene. Diseases associated with ETV3 include Subclavian Steal Syndrome. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ERF.

ets variant 3

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Cell differentiation Source: GO_Central
Cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus