FASTK

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq]

Fas-activated serine/threonine kinase

Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

Isoform 4:
Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.

Apoptotic signaling pathway Source: ProtInc
Protein phosphorylation Source: UniProtKB
Regulation of mitochondrial mRNA stability Source: InterPro
Regulation of RNA splicing Source: UniProtKB

Isoform 4: Mitochondrion matrix. Colocalizes with mitochondrial RNA granules.

Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.