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Mouse Anti-FASTK (AA 67-155) Recombinant Antibody (CBXF-0346) (CBMAB-F0339-CQ)

This product is a mouse antibody that recognizes FASTK (AA 67-155). The antibody CBXF-0346 can be used for immunoassay techniques such as: ELISA, WB.
See all FASTK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0346
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 67-155

Target

Full Name
Fas-activated serine/threonine kinase
Introduction
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
Entrez Gene ID
10922
UniProt ID
Q14296
Alternative Names
Fas Activated Serine/Threonine Kinase; Fas-Activated Serine/Threonine Kinase; FAST Kinase; EC 2.7.11.8; FAST;
Research Area
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.

Isoform 4:
Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
Biological Process
Apoptotic signaling pathway Source: ProtInc
Protein phosphorylation Source: UniProtKB
Regulation of mitochondrial mRNA stability Source: InterPro
Regulation of RNA splicing Source: UniProtKB
Cellular Location
Isoform 4: Mitochondrion matrix. Colocalizes with mitochondrial RNA granules.
PTM
Autophosphorylated on serine/threonine residues. Activated by dephosphorylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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